0083 Longitudinal sleep instability is associated with increased MRI-visible perivascular space burden
نویسندگان
چکیده
Abstract Introduction Emerging data from our group found longitudinal sleep variability within the Seattle Longitudinal Study was significantly associated with cognitive impairment and predicted 10-years downstream. While this supports a link between instability, aging, decline, mechanism linking these processes is unknown. MRI-visible perivascular space (PVS) burden putative marker of glymphatic dysfunction, previous studies suggest that disruption PVS burden. Methods This secondary analysis subjects who a) participated in b) had T1-weighted 3 T MRI FLAIR scans available for (n=250). We evaluated (standard deviation) each participant’s self-reported duration. White matter were semi-automated segmentation algorithm, accounting total (number/cm3), volume (mm3/cm3), as well average width, length, median across participants, blinded by group. Participants stratified into low or high-sleep groups. Results Preliminary (n=37) demonstrated significant association high increased whole-brain (p=0.04), participants exhibiting an 7 11.33. Follow-up features wider cohort. Conclusion These findings duration may exert previously unappreciated influence on pathological processes, potentially including dysfunction. Future cohort will seek to evaluate changes longitudinally-collected MRIs. Additional should be performed evaluating independent assess whether different time scales (weeks, years, decades) exerts similar effects outcomes. Support (if any)
منابع مشابه
Severe MRI-visible perivascular spaces due to cerebral amyloid angiopathy.
To cite: Datta S, Ramadan H, Werring DJ. Pract Neurol 2015;15:74–75. SUMMARY MRI-visible perivascular spaces are a recently recognised neuroimaging marker of cerebral small vessel diseases and centrum semiovale MRI-visible perivascular spaces may be a neuroimaging marker of cerebral amyloid angiopathy. We report an elderly woman with speech and memory disturbance, whose MR scan of brain showed ...
متن کاملPeriodic Limb Movements in Sleep is Associated with Increased Mortality
OBJECTIVE To elucidate the association between periodic limb movements in sleep (PLMS) and mortality. METHODS Nocturnal polysomnographic recordings of 1,344 subjects obtained from 1995 to 2008 were reviewed. The subjects were divided into four groups based on PLMS and insomnia: reference group (PLMS≤5), insomnia group (PLMS≤5 with insomnia symptoms), 515 group. We...
متن کاملTeaching NeuroImages: MRI-visible Virchow-Robin perivascular spaces in cerebral small-vessel disease.
MRI-visible perivascular spaces (PVS) in centrum semiovale white matter (CS) have been proposed as a novel neuroimaging marker for cerebral amyloid angiopathy (CAA). Progressive b-amyloid deposition in small cortical and leptomeningeal arteries in CAA may gradually impair perivascular drainage and cause retrograde PVS dilation. We describe the neuroimaging findings of 2 patients who were diagno...
متن کاملAmyloid burden is associated with self-reported sleep in nondemented late middle-aged adults.
Midlife may be an ideal window for intervention in Alzheimer's disease (AD). To determine whether sleep is associated with early signs of AD neuropathology (amyloid deposition) in late midlife, we imaged brain amyloid deposits using positron emission tomography with [C-11]Pittsburgh Compound B (PiB), and assessed sleep with the Epworth Sleepiness Scale and the Medical Outcomes Study Sleep Scale...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Sleep
سال: 2023
ISSN: ['0302-5128']
DOI: https://doi.org/10.1093/sleep/zsad077.0083